| Customization: | Available |
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| CAS No.: | 18162-48-6 |
| Formula: | C6h15clsi |
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Specifications:
| Items | Control Standard | |
| Appearance | White crystal | |
| Purity(GC), % | ≥ 99.0 | |
| t -Butyldimethylsilanol(GC), % | ≤ 0.5 | |
tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.tert-Butyldimethylsilyl chloride is a derivative of the silylating agent trimethylsilyl chloride (TMSCl) and is commonly used in organic synthesis to protect hydroxyl groups (-OH) in alcohols, phenols, and carbohydrates. It reacts with the hydroxyl group to form a silyl ether, which is stable under various reaction conditions.
Application:
tert-Butyldimethylsilyl chloride (TBDMS chloride) has several applications in organic synthesis, particularly as a protecting group for hydroxyl groups (-OH). Here are some common applications of tert-Butyldimethylsilyl chloride:
1. Protection of Alcohols: TBDMS chloride is widely used to protect alcohols by converting them into silyl ethers. This protection strategy allows selective reactions to be performed on other functional groups in the presence of the alcohol group.
2. Protection of Phenols: Phenols can be protected using TBDMS chloride to prevent unwanted reactions during synthetic transformations. The silyl protection is stable under various reaction conditions and can be easily removed when desired.
3. Protection of Carbohydrates: Carbohydrates often contain hydroxyl groups that can undergo undesired reactions. TBDMS chloride is commonly employed to protect these hydroxyl groups in carbohydrate chemistry, allowing for selective modifications and transformations.
4. Stereoselective Transformations: TBDMS chloride can be utilized in stereoselective transformations, where the silyl group can influence the regioselectivity or stereochemistry of a reaction.
5. Synthesis of Organosilicon Compounds: TBDMS chloride serves as a precursor for the synthesis of various organosilicon compounds, which find applications in materials chemistry, pharmaceuticals, and agrochemicals.
Storage:
Store TBDMS chloride in a cool, dry, and well-ventilated area away from sources of heat and ignition. Keep it tightly sealed in its original container to prevent moisture and air from entering. Store it away from incompatible materials such as water, acids, and oxidizing agents. It's important to note that TBDMS chloride is a highly reactive compound that can react violently with water or other incompatible materials. It should be handled with extreme care, and appropriate safety measures should be taken when storing or transporting it.
FAQ:
Q: What is the Minimum Order Quantity (MOQ)?
A: The MOQ is 1000KG.
Q: How can I obtain a sample?
A: We offer samples up to 500g for free. To receive one, please provide your DHL account for freight collection, or cover the courier costs upfront. These costs will be refunded upon placement of a bulk order.
Q: What is the lead time for orders?
A: Typically, orders are ready to be shipped approximately two weeks after receipt of the prepayment or Letter of Credit (L/C). However, this timeframe may vary by up to one week earlier or later, depending on production schedules.
Q: What are the bulk packaging options?
A: For bulk orders, packaging varies depending on the product form. Liquid products are packaged in 200-liter polythene plastic drums, with a net weight of 250kg per drum, or in 1250kg IBC Tanks, ensuring safe and efficient transportation. For powder products, we typically use 25KG Kraft paper bags, 25KG cardboard drums, or 1MT polypropylene bags, accommodating different handling and shipping requirements.
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Q: Can the packaging be customized?
A: Yes, packaging can be customized to meet the specific needs of our clients. This includes options for different container sizes, materials, and labeling services. Please discuss your requirements with us in advance to ensure we can accommodate your needs.
Q: Is there a discount for large orders?
A: We offer volume discounts for large orders. The discount rate depends on the order quantity and product specifications. Please contact our sales team with your order details to discuss potential discounts and pricing.
Q: What quality certifications do you have?
A: Our products and manufacturing processes are certified by international standards such as ISO 9001 for quality management systems and ISO 14001 for environmental management systems. Specific product certifications and compliance documents are available upon request.
Q: How can I track my order?
A: Once your order is shipped, we will provide you with a tracking number and shipping details. You can track your order through the carrier's website or contact our customer service team for updates on your shipment's status.
Q: What shipping methods do you offer, and what are the terms of transport?
A: We offer versatile shipping options to accommodate the diverse needs of our clients, including sea freight, air freight, and land transportation. For sea freight, we support all major ports in China, ensuring comprehensive coverage for international shipping. Our land transportation options include both rail and road freight, providing flexibility for domestic and cross-border deliveries. Regarding transport terms, we are equipped to handle a variety of Incoterms, including FOB (Free On Board), CIF (Cost, Insurance, and Freight), CFR (Cost and Freight), DDP (Delivered Duty Paid), FCA (Free Carrier), and EXW (Ex Works), allowing us to tailor shipping and logistics services to meet specific requirements.
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